Parenteral Quinacrine in Malarial Fevers

Further Observations on Parenteral Paludrine Hydrochloride in Malarial Fevers

A preliminary report on 52 cases of malarial fevers treated with parenteral paludrine in a dose of 15 cc. (0.1 gm. per tablet) was published in the Indian Medical Gazette (Basu Mullick and Gupta, 1947). This communication gives the results of the continuation of the trial on a further series of 191 cases in different doses during the latter part of 1947 at the Ludlow Jute Mills, Chengail. Solut...

Repurposing the anti-malarial drug, quinacrine: new anti-colitis properties

BACKGROUND Ulcerative colitis (UC) is a chronic inflammatory bowel disease that is associated with an increased risk of colorectal cancer in 8-10 years after disease onset. Current colitis treatment strategies do not offer a cure for the disease, but only treat the symptoms with limited success and dangerous side-effects. Also, there is no preventive treatment for either UC or colorectal cancer...

Malarial Fevers and Malarial Parasites

On Certain Points in Connection with Malarial Fevers in India

will suggest itself to you that such a comprehensive subject as Indian fevers could be touched on only in the slightest and most superficial manner, in the brief space accorded me. Instead, therefore, of endeavouring to wander discursively through the wide domain of Indian fevers generally, I shall attempt to limit my remarks to some few, select, points in the history of what is par excellence ...

Quinacrine: sclerosing agent of the utero-tubal junction in women, with anticarcinogenic actions in transplanted tumors in mice.

Quinacrine, an acridine derivative that was in widespread use as an anti-malarial, has been shown to have both sclerosant and anticarcinogenic actions. The sclerosant action of quinacrine has been used to produce occlusion of Fallopian tube in both experimental animals and women, and several clinical studies are reviewed. Both actions of quinacrine are potentiated by steroidal and non-steroidal...